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dc.contributor.authorDesai, N C-
dc.contributor.authorPandya, M R-
dc.contributor.authorPatel, B Y-
dc.contributor.authorBhatt, M J-
dc.contributor.authorKarkar, T J-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractThe title compounds N,N-dimethyl-1-(5-methyl-2-arylimidazo[1,2-a]pyridin-3-yl)methanamines have been synthesized by reaction of α-haloketones with 6-methylpyridin-2-amine followed by a series of multistep reactions giving the targeted compounds (4a-l). All the synthesized compounds have been screened for their in vitro antibacterial activity against E. coli, S. aureus, P. aeruginosa, S. pyogenes and antifungal activity against C. albicans, A. niger and A. clavatus. The structures of the synthesized compounds have been confirmed by spectral data IR, 1H and 13C NMR and mass spectra. Investigation of antimicrobial activity reveals that the compounds 4b, 4c, 4d, 4e and 4j show significant activities against tested organisms as compared to standard drugs like ampicillin and griseofulvin.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.55B(09) [September 2016]en_US
dc.subjectPhenacyl bromidesen_US
dc.subjectAntibacterial activityen_US
dc.subjectAntifungal activityen_US
dc.subjectSAR studyen_US
dc.titleSynthesis of novel N,N-dimethyl-1-(5-methyl-2-arylimidazo[1,2-a]pyridin-3-yl)methanamine derivatives as potential antimicrobial agentsen_US
Appears in Collections:IJC-B Vol.55B(09) [September 2016]

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