Synthesis of novel <i>N</i>,<i>N</i>-dimethyl-1-(5-methyl-2-arylimidazo[1,2-<i>a</i>]pyridin-3-yl)methanamine derivatives as potential antimicrobial agents

Abstract

The title compounds <i>N</i>,<i>N</i>-dimethyl-1-(5-methyl-2-arylimidazo[1,2-<i>a</i>]pyridin-3-yl)methanamines have been synthesized by reaction of α-haloketones with 6-methylpyridin-2-amine followed by a series of multistep reactions giving the targeted compounds <b>(4a-l)</b>. All the synthesized compounds have been screened for their <i>in vitro</i> antibacterial activity against <i>E. coli</i>, <i>S. aureus</i>, <i>P. aeruginosa</i>, <i>S. pyogenes</i> and antifungal activity against <i>C. albicans</i>, <i>A. niger</i> and <i>A. clavatus</i>. The structures of the synthesized compounds have been confirmed by spectral data IR, ¹H and ¹³C NMR and mass spectra. Investigation of antimicrobial activity reveals that the compounds <b>4b</b>, <b>4c</b>, <b>4d</b>, <b>4e</b> and <b>4j</b> show significant activities against tested organisms as compared to standard drugs like ampicillin and griseofulvin.