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Title: Phytomitogen induced changes in levels of inositol phosphates in the bovine lymphocytes
Authors: Dhingra, Jyotsna Behl nee
Verma, N K
Behl, Rahul
Prasad, S K
Ahlawat, S P S
Keywords: Inositol phosphates;Phosphatidyl inositols
Issue Date: Jun-2005
Publisher: CSIR
IPC Code: C07K 14/42, C07 C35/16
Abstract: The changes in levels of inositol phosphates and phosphoinositides were studied in the bovine lymphocytes, in response to phytomitogens (lectins)-concanavalinA (conA) and phytohaemagglutinin (PHA). Addition of conA and PHA resulted in a rapid increase in the cpm of total inositol phosphates (from 8599 ± 100 cpm/2  10⁶ cells to 11228 ± 126 cpm/2 10⁶ and 9758 ± 100 cpm/2 10⁶ cells, respectively) at 1 min after mitogen stimulation. There was a concomitant decrease in the phosphatidylinositol levels at 1 min, which continued up to 5 min. At 1 min of stimulation, inositol diphosphate fraction exhibited maximum increase, as compared to inositol mono- and triphosphates, suggesting that it contributed the most towards the overall increase in the total inositol phosphates levels. Results suggest that bovine lymphocytes respond to phytomitogens with a rapid turnover of phosphoinositides.
Page(s): 173-177
ISSN: 0301-1208
Appears in Collections:IJBB Vol.42(3) [June 2005]

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