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Title: | Phytomitogen induced changes in levels of inositol phosphates in the bovine lymphocytes |
Authors: | Dhingra, Jyotsna Behl nee Verma, N K Behl, Rahul Prasad, S K Ahlawat, S P S |
Keywords: | Inositol phosphates;Phosphatidyl inositols |
Issue Date: | Jun-2005 |
Publisher: | CSIR |
IPC Code: | C07K 14/42, C07 C35/16 |
Abstract: | The changes in levels of inositol phosphates and phosphoinositides were studied in the bovine lymphocytes, in response to phytomitogens (lectins)-concanavalinA (conA) and phytohaemagglutinin (PHA). Addition of conA and PHA resulted in a rapid increase in the cpm of total inositol phosphates (from 8599 ± 100 cpm/2 10⁶ cells to 11228 ± 126 cpm/2 10⁶ and 9758 ± 100 cpm/2 10⁶ cells, respectively) at 1 min after mitogen stimulation. There was a concomitant decrease in the phosphatidylinositol levels at 1 min, which continued up to 5 min. At 1 min of stimulation, inositol diphosphate fraction exhibited maximum increase, as compared to inositol mono- and triphosphates, suggesting that it contributed the most towards the overall increase in the total inositol phosphates levels. Results suggest that bovine lymphocytes respond to phytomitogens with a rapid turnover of phosphoinositides. |
Page(s): | 173-177 |
ISSN: | 0301-1208 |
Appears in Collections: | IJBB Vol.42(3) [June 2005] |
Files in This Item:
File | Description | Size | Format | |
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IJBB 42(3) 173-177.pdf | 135.57 kB | Adobe PDF | View/Open |
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