Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/35145
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dc.contributor.authorGupta, Prashant-
dc.contributor.authorTripathi, Alok-
dc.contributor.authorAgrawal, Tripti-
dc.contributor.authorNarayan, Chandradeo-
dc.contributor.authorSingh, BM-
dc.contributor.authorKumar, Mohan-
dc.contributor.authorKumar, Arvind-
dc.date.accessioned2016-07-29T07:43:19Z-
dc.date.available2016-07-29T07:43:19Z-
dc.date.issued2016-08-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/35145-
dc.description530-536en_US
dc.description.abstractRhizome of picrorhiza along with honey prevents hepatic damage and cure the acetaminophen (paracetamol) induced hepatotoxicity by modulating the activity of hepatic enzymes. Here, we studied the in vivo effects of Picrorhiza kurroa and honey on acetaminophen induced hepatotoxicity Balb/c mice model. Hepatic histopathological observations of acetaminophen fed (day-6) group showed more congestion, hemorrhage, necrosis, distorted hepatic architecture and nuclear inclusion. Such damages were recompensed to normal by picrorhiza or honey alone or both in combinations. We observed increased activity of SGPT and SGOT in injured liver tissues, and that too was compensated to normal with picrorhiza or honey alone or both in combinations. We observed 1.27 and 1.23-fold enhanced activity of SGPT in serum and liver lysate, respectively while SGOT showed 1.66 and 1.11 fold enhanced activity. These two enzymes are signature enzymes of liver damage. Thus, our results support that honey may be used with drug picrorhiza due to its synergistic role to enhance hepatoprotective and hepatoregenerative ability along with allopathic drugs to mitigate the hepatotoxic effects.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rightsCC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.54(08) [August 2016]en_US
dc.subjectAyurvedicen_US
dc.subjectLiver damageen_US
dc.subjectHepatoprotectiveen_US
dc.subjectHepatoregenerativeen_US
dc.subjectHerbalen_US
dc.subjectKutkien_US
dc.subjectPicroliven_US
dc.subjectPicrovinen_US
dc.subjectSGPTen_US
dc.subjectSGOTen_US
dc.titleSynergistic protective effect of picrorhiza with honey in acetaminophen induced hepatic injuryen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.54(08) [August 2016]

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