Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/3430| Title: | Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles |
| Authors: | Mogilaiah, K Vidya, K Kavitha, S Kumar, K Shiva |
| Keywords: | 2-Hydrazino-3-(3-chlorophenyl)-1,8-naphthyridine;Acetophenones;1,8-naphthyridin-2-ylhydrazones;Vilsmeier-Haack reagent;1,8-naphthyridinyl-pyrazoles |
| Issue Date: | Feb-2009 |
| Publisher: | CSIR |
| Abstract: | Condensation of 2-hydrazino-3-(3-chlorophenyl)-1,8-naph¬thyridine 2 with different acetophenones in methanol containing a catalytic amount of glacial acetic acid affords the corresponding aceto¬phenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydra¬zones 3 in excellent yields. The hydrazones 3 when subjected to the Vilsmeier-Haack reaction with POCl₃-DMF gives 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles 4 in good yields. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity. |
| Page(s): | 282-285 |
| ISSN: | 0376-4699 |
| Appears in Collections: | IJC-B Vol.48B(02) [February 2009] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 48B(2) 282-285.pdf | 63.94 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.