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http://nopr.niscpr.res.in/handle/123456789/3429| Title: | Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives |
| Authors: | Sondhi, Sham M Dinodia, Monica Rani, Reshma Shukla, Rakesh Raghubir, Ram |
| Keywords: | Pyrimidines;Carrageenan;Anti-inflammatory;Analgesic |
| Issue Date: | Feb-2009 |
| Publisher: | CSIR |
| Abstract: | A number of pyrimidine derivatives 1-3, 5-19 have been synthesized by condensation of bis(2-(vinyloxy))ethylamine, cyclopropylamine, N-(2-amino-4-ethoxyphenyl)acetamide, 2-(aminomethyl thiophene), 2-thiophen ethylamine, 2-hydrazinopyridine, 1-aminonaphthalen-2-ol hydrochloride, furfuryl amine, 2-(4-imidazolyl)ethylamine, 2-picolylamine and 4-methoxyl-2-nitroaniline with various isothiocyanatoketones. These compounds have been screened for anti-inflammatory and analgesic activities. Compounds 10 and 14 have exhibited 40% and 39% anti-inflammatory and compound 11 has showed 75% analgesic activity at 100 mg/kg p.o. respectively. |
| Page(s): | 273-281 |
| ISSN: | 0376-4699 |
| Appears in Collections: | IJC-B Vol.48B(02) [February 2009] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 48B(2) 273-281.pdf | 115.47 kB | Adobe PDF | View/Open |
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