An efficient synthesis of novel carbohydrate and thiosemicarbazone hybrid benzimidazole derivatives and their antimicrobial evaluation

Abstract

<span style="font-size:11.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">A library of thiosemicarbazide hybrid <span style="font-size:11.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:mangal;mso-ansi-language:en-in;mso-fareast-language:en-us;="" mso-bidi-language:hi"="">2-(aldo-polyhydroxyalkyl)benzimidazole<span style="font-size:11.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-bidi-font-family:mangal;mso-ansi-language:en-gb;="" mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB"> derivatives have been designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds have been elucidated with the aid of elemental analysis, IR, mass and ¹H NMR spectral data. These novel synthesized compounds have been evaluated for their antibacterial activity against two gram-positive bacteria (<i>S. aureus</i> and <i>S. pyogenus</i>) and two gram-negative bacteria (<i>P. aeruginosa</i> and <i>E. coli</i>). The title compounds have also been studied for their antifungal activity against <i>C. albicans</i>, <i>A. niger</i> and <i>A. clavatus</i> using the broth dilution technique.</span></span></span>