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http://nopr.niscpr.res.in/handle/123456789/33994| Title: | Single nucleotide polymorphism of SLC11A1, CARD15, IFNG and TLR2 genes and their association with Mycobacterium avium subspecies paratuberculosis infection in native Indian cattle population |
| Authors: | Sadana, Tarun Singh, Ran Vir Singh, Shoor Vir Saxena, Vishesh Kumar Sharma, Deepak Singh, Pravin Kumar Kumar, Naveen Gupta, Saurabh Chaubey, Kundan Kumar Jayaraman, Sujata Tiwari, Ruchi Dhama, Kuldeep Bhatia, Ashok Kumar Sohal, Jagdip Singh |
| Keywords: | Host susceptibility;Genetic resistance;Indian cattle;Johne’s disease;Paratuberculosis |
| Issue Date: | Oct-2015 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Johne’s disease (JD) or paratuberculosis infection, caused by Mycobacterium avium subspecies paratuberculosis (MAP), is one of the major production diseases of domestic animals. There is lack of preventive and chemotherapeutic measures to control this infection. Hence, in recent years emphasis has been given to identify host genetic factors associated with resistance to infection. In the present study, we analyzed SNPs in four candidate genes (SLC11A1, TLRs, NOD2/CARD and IFNγ) in case and control population of native breeds of cattle. Of the four genes only SNP in TLR2 gene showed significant association with resistance to paratuberculosis infection. The results of the present study are promising and it is predicted that such studies will serve as guidelines in future breeding programmes. |
| Page(s): | 469-475 |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Appears in Collections: | IJBT Vol.14(4) [October 2015] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBT 14(4) 469-475.pdf | 66.52 kB | Adobe PDF | View/Open |
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