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Title: Synthesis and antimicrobial activity of some thiazole and 1,3,4-oxadiazole hybrid heterocycles
Authors: Desai, N C
Bhatt, N B
Somani, H C
Bhatt, K A
Keywords: Thiazole;1,3,4-oxadiazole;Hybrid molecules;Antibacterial activity;Antifungal activity;MIC
Issue Date: Jan-2016
Publisher: NISCAIR-CSIR, India
Abstract: Among the 5-membered nitrogen heterocycles, the privileged scaffolds thiazole and 1,3,4-oxadiazole have been incorporated in a single molecular framework to explore new potential antimicrobial agents. The newly synthesized compounds 5a-l have been synthesized and characterized by IR, 1H and 13C NMR spectroscopy and mass spectrometry. The structures of the synthesized compounds are in full agreement with proposed structures and they have been evaluated for their in vitro antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and antifungal activity against Candida albicans, Aspergillus niger and Aspergillus clavatus using serial broth dilution method.
Page(s): 94-101
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(01) [January 2016]

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