<i>In vitro</i> antiproliferative activity of saffron extracts against human acute lymphoblastic T-cell human leukemia

Abstract

<span style="font-size:11.0pt;font-family: " times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;letter-spacing:-.1pt;mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB">Cancer is still considered as one of the most life threatening cause responsible for a huge number of annual deaths around the world. Particularly, leukemia is difficult to be cured. In this context, free radicals are one of the factors that cause or predispose to cancer. Hence, they should be controlled in the body by prophylactic or curative treatments. The aim of this study was to evaluate the antiproliferative effect against human acute lymphoblastic T-cell leukemia (<i>Jurkat </i>cell line) of the Lebanese saffron (<i>Crocus sativus</i> L.; Family Iridacea), and to detect which components of saffron are responsible for the growth inhibitor. Lebanese saffron decreased cell growth of <i>Jurkat </i>cells in a dose dependent manner. A mixture of crocin and safranal also decreased the number of <i>Jurkat</i> cells and the IC₅₀value of this mixture was lower than that of the whole saffron extract.</span>