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Title: Synthesis of novel pyrimidine and pyrazole hybrids as potential antimicrobial agents
Authors: Desai, N C
Vaghani, H V
Bhatt, K A
Rajpara, K M
Joshi, V V
Keywords: Pyrimidine;Pyrazole;Antibacterial activity;Antifungal activity;MIC;Hybrid molecules
Issue Date: May-2015
Publisher: NISCAIR-CSIR, India
Abstract: As a part of the ongoing endeavours in the exploration of novel antimicrobial agents, herein is reported a novel synthesis of hybrid molecules 5-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbonyl)-4-(4-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-ones 4 by combining pyrimidine and pyrazole scaffolds having diverse pharmacological activities. The characterization of these newly synthesized compounds has been carried out by IR, 1H and 13C NMR and mass spectroscopy. All the synthesized compounds have been evaluated for their in vitro antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) using serial broth dilution method. Among all these synthesized compounds 4l and 4d have emerged as highly potent molecules with 12.5 μg/mL potency against Pseudomonas aeruginosa and Aspergillus niger respectively.
Page(s): 643-649
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(05) [May 2015]

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