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http://nopr.niscpr.res.in/handle/123456789/31359| Title: | Comparative studies of synthesis of symmetric 2,6-di(benzofuran-2-yl)- 4-phenyl-pyridine derivatives via pyrylium tetrafluoroborate salt and 1,5-dione derivatives |
| Authors: | Kumar, D B Aruna Desai, Nivedita R Krishnaswamy, G Sreenivasa, S Mahadevan, K M |
| Keywords: | 2-Acetylbenzofuran;Symmetric;1,5-diones;Michael addition;Pyrylium tetrafluoro borate salt;Pyridine |
| Issue Date: | Apr-2015 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A comparative study for the synthesis of symmetric 2,6-di(benzofuran-2-yl)-4-phenyl-pyridine derivatives 4a-h as antibacterial agents, has been reported by two methods. Method A follows nucleophilic substitution reaction of 2,6-di (benzofuran-2-yl)-4-phenyl-pyrilium tetrafluoroborate salt derivatives 3a-h with ammonium acetate in ether at room temperature. Method B follows cyclisation reaction of 1,5-di (benzofuran-2-yl)-3-(4-substituted-aryl)-pentane-1,5-dione derivatives 2a-h with ammonium acetate in acetic acid under reflux. It has been found that method B proceeds under mild reaction condition with short reaction time and high yield when compared to method A. The structures of the newly synthesized compounds have been characterized by spectral studies. |
| Page(s): | 538-544 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.54B(04) [April 2015] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 54B(4) 538-544.pdf | 94.67 kB | Adobe PDF | View/Open |
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