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Title: Synthesis and antiparkinsonian activity of different pyrazolinylpyridinyl indole derivatives
Authors: Kumar, Sunil
Kaur, Hemlata
Saxena, K K
Keywords: Indoles;Pyrazolinylindoles;Pyrazolinylpyridinylindoles;Antiparkinsonian activity;Acute toxicity
Issue Date: Dec-2014
Publisher: NISCAIR-CSIR, India
Abstract: 2-Methyl/ethyl-5-methoxy/ethoxy-3-(2-benzofuran-2-yl)-3-((2-substitutedphenylazo) pyrazolin-4-yl)indoles 3a-l have been prepared by the reaction of 2-methyl/ethyl-5-methoxy/ethoxy-3-((2-benzofuran-2-yl)-pyrazolin-4-yl)indoles 2a-d with various substituted benzenediazonium chlorides in presence of sodium acetate. Compounds 3a-l on reaction with different 4-aminopyridine and formaldehyde yield 2-methyl/ethyl-5-methoxy/ethoxy-3-((2-benzofuran-2-yl)-1-(pyridinylamino)methyl-3-substitutedphenylazo)-pyrazolin-4-yl)indoles 4a-l. All the newly synthesized compounds 3a-l and 4a-l have been screened for their antiparkinsonian activity. Structures of all the compounds are established by elemental and spectral (IR, 1H NMR and mass spectroscopic) analysis.
Page(s): 1596-1605
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(12) December 2014]

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