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http://nopr.niscpr.res.in/handle/123456789/29893| Title: | In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells |
| Authors: | Sharma, Vikas Hussain, Shabir Gupta, Moni Saxena, Ajit Kumar |
| Keywords: | Mentha Spp.;Cancer cells;SRB assay |
| Issue Date: | Oct-2014 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 µg/ml was evaluated against eight human cancer cell lines — A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents. |
| Page(s): | 416-419 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.51(5) [October 2014] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 51(5) 416-419.pdf | 39.34 kB | Adobe PDF | View/Open |
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