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Title: Tungstate-catalyzed oxidation of triptans with hydrogen peroxide: A novel method for the synthesis of N,N- dimethyltryptamine N-oxides
Authors: Ray, Purna Chandra
Mittapelli, Vasantha
Chauhan, Yogendra Kumar
Konudula, Babu Rao
Tyagi, Om Dutt
Keywords: Sodium tungstate;Sumatriptan N-oxide;Rizatriptan N-oxide;Zolmitriptan N-oxide;Almotriptan-N-oxide
Issue Date: Jan-2009
Publisher: CSIR
Abstract: A straight forward oxidation method of triptans have been described for the synthesis of N,N-dimethyl-2-[5-[substituted-1H-indole-3-yl]ethanamine-N-oxides using sodium tungstate and 30% aqueous hydrogen peroxide solution in the presence of methanesulphonic acid. The significance of the process is its simplicity and efficiency in isolating the triptan N-oxide derivatives as free base and as malate salt.
Page(s): 134-136
ISSN: 0376-4699
Appears in Collections: IJC-B Vol.48B(01) [January 2009]

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