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Title: Synthesis, characterization and in vitro antibacterial activity of cinnamyl amine derivatives
Authors: Singh, Krishna K
Mathela, Chandra S
Keywords: Cinnamaldehyde;Schiff base;Cinnamyl amine derivatives;Antibacterial activity
Issue Date: Jul-2014
Publisher: NISCAIR-CSIR, India
Abstract: A series of cinnamyl amine derivatives have been synthesized and characterized by their MS, 1H and 13C NMR spectral data. Antibacterial activity has been evaluated against three Gram-positive (Bacillus subtilis MTCC 121, Staphylococcus aureus MTCC 96 and Staphylococcus epidermidis MTCC 435) and two Gram-negative (Escherichia coli MTCC 723 and Pseudomonas aeruginosa MTCC 741) bacteria. The Schiff base derivatives benzyl-(3-phenylallylidene)amine 3, phenyl-(3-phenylallylidene)amine 4 and amine derivatives 2-[benzyl-(3-phenylallyl)-amino]-1-(4-methoxyphenyl)ethanone 8c and 1-(4-bromophenyl)-2-[phenyl-(3-phenylallyl)-amino]ethanone 9c showed remarkable antibacterial activity against B. subtilis, S. aureus and S. epidermidis bacterial strains even at low concentration and are close to the standard antibiotic streptomycin (MIC 3.3-7.0 μg mL-1). Furthermore, methoxy substitution at phenacyl nucleus increased the antibacterial activity as compared to the methyl and bromo substituents under identical conditions.
Page(s): 907-912
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(07) [July 2014]

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