<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-US">Synthesis, characterization and <i style="mso-bidi-font-style:normal">in vitro</i> antibacterial activity of cinnamyl amine derivatives</span>

Abstract

A series of cinnamyl amine derivatives have been synthesized and characterized by their MS, ¹H and ¹³C NMR spectral data. Antibacterial activity has been evaluated against three Gram-positive (<i style="mso-bidi-font-style:normal">Bacillus subtilis</i> MTCC 121, <i style="mso-bidi-font-style:normal">Staphylococcus aureus</i> MTCC 96 and <i style="mso-bidi-font-style:normal">Staphylococcus epidermidis</i> MTCC 435) and two Gram-negative (<i style="mso-bidi-font-style: normal">Escherichia coli</i> MTCC 723 and <i style="mso-bidi-font-style:normal">Pseudomonas</i> <i style="mso-bidi-font-style:normal">aeruginosa</i> MTCC 741) bacteria. The Schiff base derivatives benzyl-(3-phenylallylidene)amine <b style="mso-bidi-font-weight:normal">3</b>, phenyl-(3-phenylallylidene)amine <b style="mso-bidi-font-weight:normal">4</b> and amine derivatives 2-[benzyl-(3-phenylallyl)-amino]-1-(4-methoxyphenyl)ethanone <b style="mso-bidi-font-weight:normal">8c</b> and 1-(4-bromophenyl)-2-[phenyl-(3-phenylallyl)-amino]ethanone <b style="mso-bidi-font-weight: normal">9c</b> showed remarkable antibacterial activity against <i style="mso-bidi-font-style:normal">B. subtilis</i>,<i style="mso-bidi-font-style: normal"> S. aureus</i> and<i style="mso-bidi-font-style:normal"> S. epidermidis</i> bacterial strains even at low concentration and are close to the standard antibiotic streptomycin (MIC 3.3-7.0 μg mL^-1). Furthermore, methoxy substitution at phenacyl nucleus increased the antibacterial activity as compared to the methyl and bromo substituents under identical conditions.