Hepatoprotective activity of <i style="mso-bidi-font-style:normal">Oxalis corniculata</i> L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its <i style="mso-bidi-font-style:normal">in vitro</i> antioxidant effects

Abstract

<i style="mso-bidi-font-style:normal">Oxalis corniculata</i> is well known for its medicinal properties like anti-inflammatory, digestive, diuretic, antibacterial, antiseptic etc. The present study focuses on the ability of <i style="mso-bidi-font-style:normal">O. corniculata</i> to alleviate liver damage caused by over dose of paracetamol. Antioxidant activity of <i style="mso-bidi-font-style:normal">O. corniculata</i> was evaluated using the free radical scavenging activity of 1, 1-diphenyl-2- picrylhydrazyl radicals, total anti oxidant capacity by phosphomolybdenum method and total phenolic content was also evaluated. The ethanolic extract of whole plant of <i style="mso-bidi-font-style:normal">O. corniculata</i> (OC, 500 µg/mL, po) significantly reduced 1, 1-diphenyl-2- picrylhydrazyl radicals. This dose also caused significant reduction (62.67%) in malondialdehyde levels of murine hepatic tissues. The antioxidant capacity of OC was comparable to that of standard ascorbic acid and showed 53.5 µg of phenol/mg OC. Rats pre-treated with OC for 4 days showed significant reduction in the serum enzymes such as glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, serum bilirubin and showed almost normal histological liver architecture of the treated groups compared to paracetamol induced hepatic damage group, indicating its hepatoprotective and antioxidant potential.