Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/26381| Title: | Ribozymes-A New Approach for Modulating Gene Expression |
| Authors: | Singh, Yashveer Misra, Arvind Tripathi, Snehlata Misra, Krishna |
| Issue Date: | Oct-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Specific inactivation of gene expression through ribozymes is a relatively novel approach. Specially designed ribozymes can be used to bind and bring out site specific cleavage of target viral mRNA. Recent reports suggest that ribozymes can be used effectively in cell culture against a variety of RNA targets, including, viral, endogenous and transfected sequences. Besides, destroying mRNA. they can be used to repair mutant RNAs as well, Of many catalytic motifs, hairpin and hammerhead appears to be more promising as therapeutic agents and are being tested in clinical trials. |
| Page(s): | 775-785 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Appears in Collections: | JSIR Vol.61(10) [October 2002] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JSIR 61(10) 775-785.pdf | 2.72 MB | Adobe PDF | View/Open |
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