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Title: Protective effect of secondary plant metabolites from Ipomoea aquatica Forsk. against carbofuran induced damages
Authors: Datta, Sanjukta
Sinha, Mahuya
Das, Dipesh
Ghosh, Santinath
Dhar, Pubali
Keywords: Antioxidant enzymes;Carbofuran;Flavonoids;Lipid peroxidation;Oxidative stress
Issue Date: Dec-2013
Publisher: NISCAIR-CSIR, India
Abstract: Plausible interactions between food contaminants and natural constituents in vivo and protective effect of polyphenols present in I. aquatica against carbofuran toxicity in Charles Foster rats were evaluated. Determinations based on antioxidant enzyme activities showed significant alterations in glutathione, glutathione peroxidase, superoxide dismutase and catalase in tissues (liver and brain) and plasma of pesticide treated group while polyphenolic extracts from I. aquatica (IAE) attenuated their activities when given alongwith carbofuran. IAE decreased enhanced lipid peroxidation levels in plasma and erythrocyte membrane and cholesterol levels in brain and plasma. IAE also minimized histopathological degenerative changes produced by carbofuran. While single cell gel electrophoresis showed that secondary metabolites in leafy vegetables produced a combinatorial effect with pesticide at cellular level, DNA fragmentation level in bone marrow cells showed a decline in the IAE treated rats. Food safety adversely affected by various chemical contaminants can be retained by plant polyphenols and secondary plant constituents that can be found together in bolus. Therefore, the present study gives an insight into the protective role of naturally found polyphenols against pesticide toxicity.
Page(s): 1109-1119
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.51(12) [December 2013]

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