<i><span style="font-size:21.5pt;mso-bidi-font-size:14.5pt;font-family:"Times New Roman","serif"">Mycobacterium phlei </span></i><span style="font-size:21.5pt;mso-bidi-font-size:14.5pt; font-family:"Times New Roman","serif"">as an oral immunomodulator with Newcastle disease vaccine </span>

Abstract

<span style="font-size: 15.5pt;mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman","serif""="">Experiments were conducted in chickens to understand the effects of oral immunomodulation. Heat inactivated <i>M phlei, </i>a commensal Mycobacterium and a non-specific immunomodulator, was administered orally prior to live Newcastle disease F (ND F) strain vaccination. In experimental birds it lead to an enhanced cell mediated Immune response (CMI) against the vaccine. There was a reduction in the Haemagglutination inhibiting (HI) antibodies. However, it did not affect the protection against a virulent challenge, as the protection percentage was more or less same in vaccinated birds irrespective of the <i>M.phlei </i>administration. <i>M.phlei </i>administration could not enhance the immune response to inactivated ND F vaccine administered orally. The results indicate that <i>M.phlei </i>favours a CMI response to orally administered live ND F vaccine. <span style="font-size:15.0pt;mso-bidi-font-size:8.0pt;font-family:" arial","sans-serif""="">It <span style="font-size:15.5pt;mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman","serif""="">may be of potential use in enhancing CMI against vaccines and a cheaper alternative to costlier recombinant cytokines.

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