Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/24041| Title: | Mycobacterium phlei as an oral immunomodulator with Newcastle disease vaccine |
| Authors: | Sreekumar, E Das, S K |
| Issue Date: | Oct-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Experiments were conducted in chickens to understand the effects of oral immunomodulation. Heat inactivated M phlei, a commensal Mycobacterium and a non-specific immunomodulator, was administered orally prior to live Newcastle disease F (ND F) strain vaccination. In experimental birds it lead to an enhanced cell mediated Immune response (CMI) against the vaccine. There was a reduction in the Haemagglutination inhibiting (HI) antibodies. However, it did not affect the protection against a virulent challenge, as the protection percentage was more or less same in vaccinated birds irrespective of the M.phlei administration. M.phlei administration could not enhance the immune response to inactivated ND F vaccine administered orally. The results indicate that M.phlei favours a CMI response to orally administered live ND F vaccine. It may be of potential use in enhancing CMI against vaccines and a cheaper alternative to costlier recombinant cytokines. |
| Page(s): | 989-992 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.39(10) [October 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 39(10) 989-992.pdf | 1.02 MB | Adobe PDF | View/Open |
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