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Title: Semecarpus anacardium L, nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property
Authors: Tripathi, Y B
Pandey, R S
Keywords: Anti-atherosclerotic;Anti-inflammatory;Herbal medicine;Hypolipidemic;Macrophage function;Nitric oxide;Semecarpus anacardium
Issue Date: Apr-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.7 A61K 35/00
Abstract: Traditionally S. anacardium is used for rejuvenation, rheumatoid arthritis, fever and neurological disorders. In the present study it was observed that a fraction of S. anacardium at dose of 1mg/100g body wt, significantly reduced serum cholesterol from 378.87 mg/dl in the rats fed with atherogenic diet (AD) to 197.99 mg/dl (45-52%) in the rats fed with AD diet and increased serum HDL-cholesterol (33-37%). The same fraction also inhibited LPS induced NO production in the culture activated rat peritoneal macrophages in the dose dependent manner with IC50 value at 50ng/ml of the culture medium. The drug in the above doses was completely safe and non-toxic, (no change in the enzymes), to liver and kidney functions.
Page(s): 432-436
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(04) [April 2004]

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