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http://nopr.niscpr.res.in/handle/123456789/23425| Title: | Semecarpus anacardium L, nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property |
| Authors: | Tripathi, Y B Pandey, R S |
| Keywords: | Anti-atherosclerotic;Anti-inflammatory;Herbal medicine;Hypolipidemic;Macrophage function;Nitric oxide;Semecarpus anacardium |
| Issue Date: | Apr-2004 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.7 A61K 35/00 |
| Abstract: | Traditionally S. anacardium is used for rejuvenation, rheumatoid arthritis, fever and neurological disorders. In the present study it was observed that a fraction of S. anacardium at dose of 1mg/100g body wt, significantly reduced serum cholesterol from 378.87 mg/dl in the rats fed with atherogenic diet (AD) to 197.99 mg/dl (45-52%) in the rats fed with AD diet and increased serum HDL-cholesterol (33-37%). The same fraction also inhibited LPS induced NO production in the culture activated rat peritoneal macrophages in the dose dependent manner with IC50 value at 50ng/ml of the culture medium. The drug in the above doses was completely safe and non-toxic, (no change in the enzymes), to liver and kidney functions. |
| Page(s): | 432-436 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.42(04) [April 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 42(4) 432-436.pdf | 1.32 MB | Adobe PDF | View/Open |
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