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Title: | Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb. |
Authors: | Pungle, Pratibha Banavalikar, M Suthar, A Biyani, M Mengi, S |
Keywords: | Anti -anaphylactic activity;Boswellic acid; Boswellia serrata;Mast cell stabilizing activity |
Issue Date: | Dec-2003 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto β- boswellic acid (KBA), acetyl β- boswellic acid and β- boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20,40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependent manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (SO mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising anti anaphylactic and mast cell stabilizing activity of the extract. |
Page(s): | 1460-1462 |
ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
Appears in Collections: | IJEB Vol.41(12) [December 2003] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 41(12) 1460-1462.pdf | 692.25 kB | Adobe PDF | View/Open |
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