Please use this identifier to cite or link to this item:
Title: Analgesic activity of Piper longum Linn. root
Authors: Vedhanayaki, G
Shastri, Geetha V
Kuruvilla, Alice
Keywords: Analgesic activity;Pentazocine;Piper longum ;NSAID;Thermal stimulus
Issue Date: Jun-2003
Publisher: NISCAIR-CSIR, India
Abstract: Piper longum  root, commonly called Kandantippili , is traditionally used to treat rheumatism, insomnia, palsy and epilepsy. But a scientific study on its central actions is not available. This study screens P. longum root for opioid type analgesia using rat tail-flick method and for NSAID type analgesia using aceti c-acid writhing method. Pentazocine (ip) and ibuprofen (oral) are used as respective drug controls. An aqueous suspension of P. longum root powder is given orally to mice and rat in doses of 200,400 and 800 mg/kg. The delay in reaction time for thermal stimulus in rats and the number of writhings to chemical stimulus in mice are determined in each group. The results are analysed statistically. The 400 and 800 mg/kg doses of P. longum show significant NSAID type of analgesia (P < 0.001). Both Ibuprofen (40 mg/kg) and P. longum (800 mg/kg) show 50% protection against writhing. The delay in reaction time to thermal stimulus was less than 6% for different doses of P. longum as against 100% for pentazocine. This indicates that P. longum root has weak opioid but potent NSAID type of analgesic activity.
Page(s): 649-651
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(06) [June 2003]

Files in This Item:
File Description SizeFormat 
IJEB 41(6) 649-651.pdf742.58 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.