Effect of <i>Aloe vera </i>(L.) Burm. fil. leaf gel and pulp extracts on kidney in type-II diabetic rat models

Abstract

Significant degenerative changes were observed in the kidney tissue of untreated neonatal streptozotocin (n0STZ)induced type-II diabetic rats. These degenerative changes were diminished in the kidney tissue of diabetic animals given glibenclamide and <i>Aloe </i>leaf gel and pulp extracts. Kidney lipid peroxidation levels were increased in diabetic rats compared to healthy rats; these levels were higher in rats treated with glibenclamide than in those which received <i>Aloe </i>extracts. Serum urea and creatinine levels were higher in diabetic rats in comparison to healthy rats. The administration of <i>Aloe </i>gel extract and glibenclamide decreased serum urea and creatinine levels in comparison to diabetic controls. Only <i>A. vera </i>leaf gel extract showed improvement both in histological and biochemical parameters suggesting a protective effect of <i>A. vera </i>on mild damage caused by type-II diabetes on kidney tissue.