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Title: Chemical transformation of andrographolide
Authors: Pal, Mahesh
Singh, Meenakshi
Sharma, R P
Issue Date: Sep-2002
Publisher: NISCAIR-CSIR, India
Abstract: Tosylation of andrographolide 1, with p-TsCl pyridine furnishes compounds 3 and 4. The reaction of 1 with in situ generated nickel boride yields compounds 6 and 8. Monotosylation of 6 followed by reaction with NaI refluxing in acetone furnishes the iodide 13. But all attempts to generate an oxetane moiety in 13 corresponding to compund 2 failed.
Page(s): 1915-1918
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.41B(09) [September 2002]

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