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http://nopr.niscpr.res.in/handle/123456789/21827| Title: | Condensed heterocyclic systems containing bridgehead nitrogen atom: Synthesis and antimicrobial activity of s-triazolo[3,4-b][1, 3,4] thiadiazines, thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles |
| Authors: | Mohan, Jag |
| Issue Date: | Feb-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The synthesis of 2-p-fluorophcnyl-5-p-bromophenylthiazolo[3,2-b]-s-triazole 5 has been achieved starting from 3-p-fluorophenyl-5-mercapto-s-triazole 3. Compound 3 on condensation with p-bromophenacyl bromide gave the ketone 4 which on cyclization with PPA affords thiazolo[3,2-b]-s-triazole 5 and not the isomeric thiazolo[2,3-c]-s-triazole 7. This has been established by an unequivocal synthesis of 7 through POCl3 cyclization of 2-p-fluorobenzoylhydrazino-4-pbromophenyl thiazole hydrobromide 6. However the condensation of 4-amino-5-mercapto-3-p-fluorophenyl-s-triazole 8 with p-chlorophenacyl bromide furnishes 7H-6-p-chlorophenyl-3-p-fluorophenyl-s-triazolo[3,4,-b] [1,3,4] thi adiazine 9 in one step only. The diuretic, antibacterial and antifungal activities of these compounds have also been evaluated. |
| Page(s): | 403-406 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.41B(02) [February 2002] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 41B(2) 403-406.pdf | 782.21 kB | Adobe PDF | View/Open |
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