Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation

Abstract

A series of 5-aryl-3-cyanomethylpyrazoles have been synthesized by refluxing 6-aryl-3-cyano-4-methylthio-2<i>H</i>-pyran-2-ones with hydrazine. The active methylene moiety of these pyrazoles has further been exploited to build 1,4-disubstituted 5-amino-1 ,2,3-triazolcs <i>via </i>their base-catalyzed condensation with 3/4-nitrophenylazides. All these compounds have been characterized by detailed spectral analysis and chemical transformations to confirm their structures unambiguously, which were proposed inconclusively five decades ago. Further, these pyrazolyltriazoles have been tested as antiinvasive agents against solid tumors and as antimycobacterial agents.

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