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http://nopr.niscpr.res.in/handle/123456789/21302| Title: | Synthesis and antiviral activity of some novel substituted phenothiazines |
| Authors: | Pandey, V K Saxena, S K Joshi, M N Bajpai, S K |
| Issue Date: | May-2004 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int.Cl.7 C 07 D279/00 |
| Abstract: | Hydroquinone on reaction with amido alcohols 1 in the presence of conc. H2SO4 gives 2-arylamidolimidoalkyl-1,4-dihydroxybenzenes 2 which undergo cyclization with aromatic primary amine and sulphur in the presence of iodine to yield 2-arylamidoli midoalkyl-10H-phenothiazin-3-ols 3. Compounds 3 are further substituted to 2-arylamido/imidoalkyl-10-[(4-methoxyphenyl/phenyl) phenylamino-methyl]-10H-phenothiazin-3-ols 4.Compounds 4 have been screened for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I). |
| Page(s): | 1015-1017 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.43B(05) [May 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 43B(5) 1015-1017.pdf | 577.51 kB | Adobe PDF | View/Open |
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