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Title: Synthesis and antiviral activity of some novel substituted phenothiazines
Authors: Pandey, V K
Saxena, S K
Joshi, M N
Bajpai, S K
Issue Date: May-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D279/00
Abstract: Hydroquinone on reaction with amido alcohols 1 in the presence of conc. H2SO4 gives 2-arylamidolimidoalkyl-1,4-dihydroxybenzenes 2 which undergo cyclization with aromatic primary amine and sulphur in the presence of iodine to yield 2-arylamidoli midoalkyl-10H-phenothiazin-3-ols 3. Compounds 3 are further substituted to 2-arylamido/imidoalkyl-10-[(4-methoxyphenyl/phenyl) phenylamino-methyl]-10H-phenothiazin-3-ols 4.Compounds 4 have been screened for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I).
Page(s): 1015-1017
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.43B(05) [May 2004]

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