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http://nopr.niscpr.res.in/handle/123456789/21287| Title: | Nickel chloride hexahydrate: A novel reagent for Michael addition on α,β-unsaturated acids — A facile one-step route to 3-arylmercaptopropionic acids from thiophenols and α,β-unsaturated acids |
| Authors: | Gogia, Santosh Sirohi, Reenu Gupta, Suman Kishore, D Joshi, B C |
| Issue Date: | May-2004 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int.Cl.7 C 07 G 53/00 |
| Abstract: | Michael additions have been successfully carried out in presence of a base, but when an α,β-unsaturated acid is a substrate, it would be most unlikely for a carboxylate ion bearing α,β-unsaturated site to undergo a Michael addition. This problem has been circumvented in the present paper by carrying out a nickel chloride hexahydrate mediated Michael addition of thiophenols 1a-k on acrylic acid and on cinnamic acid to give 3-aryl mercaptopropionic acids 3a-k in excellent yield. |
| Page(s): | 1008-1011 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.43B(05) [May 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 43B(5) 1008-1011.pdf | 701.83 kB | Adobe PDF | View/Open |
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