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Title: Synthetic glutathione peroxidase mimics: Effect of nucleophilicity of the aryl thiol cofactor on the antioxidant activity
Authors: Bhabak, Krishna Pada
Bhowmick, Debasish
Mugesh, Govindasamy
Keywords: Glutathione peroxidase;Antioxidants;Organoselenium compounds;Aromatic thiols;Peroxide reduction;Thiols;Enzymatic activity;Enzyme mimics
Issue Date: 3-Aug-2013
Abstract: Catalytic activity of a series of potent amide- and amine-based organoselenium compounds are studied in the presence of various aromatic thiols having electron donating and electron withdrawing substituents on the phenyl ring. This study suggests that the antioxidant activities of the synthetic GPx mimics can be significantly increased by the incorporation of a suitable electron donating group on the phenyl ring of an aromatic thiol.
Page(s): 1019-1025
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.52A(08-09) [August-September 2013]

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