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http://nopr.niscpr.res.in/handle/123456789/19771| Title: | Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma |
| Authors: | Sharma, S K Das, M R |
| Issue Date: | Jun-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | G protein beta subunit (Gβ2) is over-expressed in Zajdela ascitic hepatoma (ZAH), a rat ascitic tumour, at mRNA as well as protein levels. Nuclear run-off transcription analysis suggests that the expression of Gβ2 in ZAH is regulated mainly at transcriptional as well as post-transcriptional levels. Gαi3 is also over-expressed in ZAH. No amplification or any change in the organization of the genes for Gβ2 or Gαi3 was observed. It is possible that the over-expression of G protein subunits in ZAH could provide proliferative advantage to the cells by virtue of their effects on second messenger systems. |
| Page(s): | 148-154 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.39(3) [June 2002] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 39(3) 148-154.pdf | 1.3 MB | Adobe PDF | View/Open |
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