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dc.contributor.authorDesai, N C-
dc.contributor.authorSatodiya, H M-
dc.contributor.authorRajpara, K M-
dc.contributor.authorJoshi, V V-
dc.contributor.authorVaghani, H V-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractA new coumarin based 3-cyanopyridine scaffolds bearing biologically active sulfonamide group has been inserted using both conventional and microwave method. Initial step involves the synthesis of 2-amino-6-(6-fluoro-2-oxo-2H-chromen-3-yl)-4-(aryl)nicotinonitriles 5a-m by reacting 3-acetyl-6-fluoro-2H-chromen-2-one 3, various aromatic aldehydes 4a-m, malononitrile and ammonium acetate. Finally compounds 5a-m are reacted with benzenesulfonyl chloride to afford targeted compounds 7a-m. These compounds have been characterized by means of IR, 1H NMR, 13C NMR and mass spectra. Newly synthesized compounds 7a-m have been screened for their antibacterial and antifungal activities against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger and Aspergillus clavatus. Compounds 7c, 7d, 7i, 7j and 7l are found to possess significant activity against tested organisms. en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rightsCC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.52B(07) [July 2013]en_US
dc.subjectAntimicrobial activityen_US
dc.titleMicrowave assisted synthesis of new coumarin based 3-cyanopyridine scaffolds bearing sulfonamide group having antimicrobial activityen_US
Appears in Collections:IJC-B Vol.52B(07) [July 2013]

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