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http://nopr.niscpr.res.in/handle/123456789/18802| Title: | Synthesis and antiviral activity of furobenzopyrones |
| Authors: | Pandey, V K Singh, V K Tandon, M Joshi, M N Bajpai, S K |
| Issue Date: | Aug-2004 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int.Cl.7 C 07 D 311/04 // A 61 P 31/12 |
| Abstract: | p-Phenylacetophenone 1 is synthesized by Friedel-Crafts acylation of diphenyl. Bromination of 1 in gl. acetic acid affords p-phenyl phenacyl bromide 2, which on reaction with 7-hydroxy-4-methyl coumarin (4-methyl umbellifcrone) has resulted in 4-methyl-7-(4'-phenylphenacyloxy)-benzo [1,2-b] pyran-2-one 3. Reaction of 3 with phosphorusoxychloride in carbon tetrachloride gives a cyclized product 2H-4-methyl-9-(p-phenyl-phenyl)-furo-[2',3',5,6]-benzo[1,2-b]pyran -2-one 4, which on treatment with aromatic aldehydes yields 2H-4-styryl-9-[p-phenyl-phenyl)-furo-[2' ,3',5,6]-benzo-[1,2-b] pyran-2- ones 5. Compounds 5 are evaluated for their antiviral activity against Japanese encephalitis virus (JEV) and Herpes simplex virus type-I (HSV-I). |
| Page(s): | 1770-1773 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.43B(08) [August 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 43B(8) 1770-1773.pdf | 748.1 kB | Adobe PDF | View/Open |
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