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http://nopr.niscpr.res.in/handle/123456789/18719| Title: | Thiadiazolyl quinazolones as potential antiviral and antihypertensive agents |
| Authors: | Pandey, V K Tusi, Sarah Tusi, Zehra Raghubir, R Dixit, M Joshi, M N Bajpai, S K |
| Issue Date: | Jan-2004 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Phthalic anhydride on treatment with β-ethanol amine gives N-hydroxy ethyl phthalimide I which reacts with anthranilic acid in presence of ethanol containing concentrated hydrochloric acid affording 5-(N-ethylphthalimido)-anthranilic acid 2. This on treatment with benzoyl chloride in pyridine gives 6-(N-ethyl phthalimido)-2-phenyl-4-oxo-3, 4-dihydrobenzoxazine 3 which on reaction with 2-amino-5 -aralkyl -1 , 3, 4-thiadiazoles 4 in pyridine results in the format ion of 6-(N-ethylphthalimido)-3- [2'-(5'-aralkyl-1', 3', 4'-thiadiazolyl)]-2 - phenyl-4-oxo-(3H)-quinazolines 5. The antiviral and antihypertensive activities of 5 have been reported. |
| Page(s): | 180-183 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.43B(01) [January 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 43B(1) 180-183.pdf | 830.6 kB | Adobe PDF | View/Open |
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