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http://nopr.niscpr.res.in/handle/123456789/18616| Title: | Formation constants and molecular modelling studies on interaction of metal ions with 6- f1uoro-7-(5-nonyl-1 ,3,4-oxadiazol-2-ylsulphanyl)-4-quinolone-3-carboxylic acid [QDA] |
| Authors: | Sharma, R K Chopra, Shilpa Kidwai, M |
| Issue Date: | Nov-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Formation constants of Cu, Ni , Co, Zn, Mn and Mg with 6-fluoro- 7 -(S-nonyl- I ,3,4-oxadiazol-2-y Isulphanyl)-4-quinolone-3- carboxylic acid have been determined using BEST program. Species distribution is plotted using programs BEST and SPE which indicates that at biological pH value, complex formation is taking place with Mg. Molecular mechanics calculations also confirm the complexation behaviour of the ligand . This supports the explanation of antibacterial mechanism through complexation of drug with Mg of bacterial DNA. |
| Page(s): | 1240-1242 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.40A(11) [November 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 40A(11) 1240-1242.pdf | 563.3 kB | Adobe PDF | View/Open |
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