Effect of <i>Aegle marmelos </i>Correa. (Bael) fruit extract on tissue antioxidants in <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">streptozotocin <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">diabetic rats</span></span>

Abstract

A study was undertaken to evaluate the anti -lipid peroxidative activity of an aqueous extract of A. <i>marmel</i><i>os </i>fruits (AMFEt) in streptozotocin diabetic rats in heart and pancreas. Oral administration of AMFEt for 30 days (125 and 250 mg

Kg^-¹ body weight twice daily) produced a significant decrease in the elevated levels of peroxidation products, viz.thiobarbituric acid reactive substances and hydroperoxides in the tissues of diabetic rats. The depressed activities of

<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">s<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">up<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">eroxide <span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">dismutase, catalase and glutathione peroxidase and <span style="font-size:14.0pt; line-height:115%;font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">lowered <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">g<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">lutathion<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">e <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">content <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">in th<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">e <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">heart <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">a<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">nd pancr<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">eas <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">of diabetic <span style="font-size:14.0pt;line-height: 115%;font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">r<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ats <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">were found <span style="font-size:14.0pt;line-height: 115%;font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">t<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">o <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">increase <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">on <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">tr<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">eatmen<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">t <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">with AMFEt. AMFEt at <span style="font-size:14.0pt; line-height:115%;font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">a <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">dose of 250 <span style="font-size:14.0pt;line-height: 115%;font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">mg <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">kg^{<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#626262;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">-1</span>}<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#626262;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN"> <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">was more <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">e<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ffe<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">c<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#1B1B1B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ti<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">ve <span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#333333;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">than glibenclamide <span style="font-size:14.0pt; line-height:115%;font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;; color:#4B4B4B;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">(300μ<span style="font-size:14.0pt;line-height:115%; font-family:&quot;Times New Roman&quot;;mso-fareast-font-family:HiddenHorzOCR;color:#4B4B4B; mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">g <span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">kg^{<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">-<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">l</span></span>}<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">) and <span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">both rev<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">e<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">r<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">se<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">d <span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">a<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ll th<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">e va<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">lue<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#626262;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">s s<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ignificantly. Thus AMFEt <span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ex<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">hibit<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">s an<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#1B1B1B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">ti-<span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#4B4B4B;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">oxidative activity <span style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;; mso-fareast-font-family:&quot;Times New Roman&quot;;color:#333333;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">in streptozotocin diabetic rats.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>