Please use this identifier to cite or link to this item:
Title: Lipid peroxidation and antioxidant systems in the blood of young rats subjected to chronic fluoride toxicity
Authors: Shivarajashankara, Y M
Shivashankara, A R
Bhat, P Gopalakrishna
Rao, S Hanumanth
Keywords: Antioxidant system;Fluoride toxicity;Fluoride in water;Lipid peroxidation
Issue Date: Aug-2003
Publisher: NISCAIR-CSIR, India
Abstract: Wistar albino rats were exposed to 30 or 100 ppm fluoride in drinking water during their fetal, weanling and postweaning stages of life up to puberty. Extent of lipid peroxidation and response of the antioxidant systems in red blood cells and plasma to prolonged fluoride exposure were assessed in these rats in comparison to the eontrol rats fed with permissible level (0.5 ppm) of fluoride. Rats treated with 100 ppm fluoride showed enhanced lipid peroxidation as evidenced by elevated malondialdehyde (MDA) levels in red blood cells but, 30 ppm fluoride did not cause any appreciable change in RBC MDA level. 30 ppm fluoride- intake resulted in increased levels of total and reduced glutathione in red blood cells and ascorbic acid in plasma while 100 ppm fluoride resulted in decreases in these levels. The activity of RBC glutathione peroxidise was elevated in both the fluoride-treated groups, more pronounced increase was seen with 100 ppm. Reduced to total glutathione ratio in RBC and uric acid levels in plasma decreased in both the groups. RBC superoxide dismutase activity decreased significantly on high- fluoride treatment. These results suggest that long-term high- fluoride intake at the early developing stages of life enhances oxidative stress in the blood, thereby disturbing the antioxidant defense of rats. Increased oxidative stress could be one of the mediating factors in the pathogenesis of toxic manifestations of fluoride.
Page(s): 857-860
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(08) [August 2003]

Files in This Item:
File Description SizeFormat 
IJEB 41(8) 857-860.pdf968.86 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.