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Title: Synthesis and antimicrobial activity of new 1-n-butyl-3-acetyl-5-(2,4-diamino-1,3,5-triazin-6-yl)methoxy-2-methylindole derivatives
Authors: Gadaginamath, G S
Kavali, R R
Pujar, S R
Issue Date: Oct-1999
Publisher: NISCAIR-CSIR, India
Abstract: 5-Hydroxyindole 1a is reacted with bromine in acetic acid to yield 6-bromo-5-hydroxyindole 1b. Compounds 1a-b are condensed with chloroacetonitrile in refluxing acetone in the presence of K2CO3 to obtain 3-acetyl-1-n-butyl-2-methylindol-5-yloxyacetonitriles 2a-b which are then reacted with dicyanodiamide in the presence of KOH in methanol and isopropanol to obtain the required 1-n-butyl-3-acetyl-5-(2,4-diamino-1,3,5-triazin-6-yl)methoxy-2-methylindoles 3a-b. All these new compounds have been screened for their antibacterial and antifungal activities.  
Page(s): 1226-1228
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.38B(10) [October 1999]

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