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dc.contributor.authorMogilaiah, K-
dc.contributor.authorReddy, P Raghotham-
dc.contributor.authorRao, R Babu-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractInteraction of 2-phenyl-1,8-naphthyridine-3-carboxylic acid hydrazide 1 with different isatins 2 gives the corresponding isatin-(2-prenyl-1,8-naphthyridine-3-carbonylhydrazones) 3. Cyclocondensation of 3 with mercaptoacetic acid in DMF in the presence of anhyd. ZnCI2 affords 3' -(2-phenyl-1,8-naphthyridine-3-carbonylamino )spiro[3 H-inole-3,2'thiazolidine ]-2,4' (1H)-diones 4, which on treatment with conc. H2S04 undergo cyclodehydration to furnish the desired 2' (2-phenyl-1,8-naphthyridin-3-yl) spiro[3H-indole-3,5' -[1,3,4]oxadiazolo[3,2-c ]thiazole]-2(1H)-ones 5. On the other hand, the hydrazones 3 on treatment with conc. H2S04 leads to the formation of 2-(2-phenyl-1,8-naphthyridin-3-yl)[1,3,4]oxadiazino[6,5-b]indoles 6. The structures of the compounds 3-6 have been established on the basis of their elemental analyses and spectral (IR, 1H NMR and mass) data. The compounds 5 and 6 have been screened for their antibacterial activity.   en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.38B(10) [October 1999]en_US
dc.titleSynthesis and antibacterial activity of some novel spiro [3H-indole-3,5'-[1 ,3,4]oxadiazolo[3,2-c]thiazole]-2(1H)-ones and [1,3,4]oxadiazino[6,5-b]indoles containing 1 ,8-naphthyridine moietyen_US
Appears in Collections:IJC-B Vol.38B(10) [October 1999]

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