Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/16552| Title: | Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats |
| Authors: | Suguna, Periyanayagam Geetha, Arumugam Aruna, Ravikumar Siva, Ganesan Vijaiyan |
| Keywords: | Antioxidants;Ethanol;High fat diet;Inflammation;Pancreatitis;Thymoquinone |
| Issue Date: | Apr-2013 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1β and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ. |
| Page(s): | 292-302 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.51(04) [April 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 51(4) 292-302.pdf | 325.65 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.