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Title: Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats
Authors: Suguna, Periyanayagam
Geetha, Arumugam
Aruna, Ravikumar
Siva, Ganesan Vijaiyan
Keywords: Antioxidants;Ethanol;High fat diet;Inflammation;Pancreatitis;Thymoquinone
Issue Date: Apr-2013
Publisher: NISCAIR-CSIR, India
Abstract: A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1β and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.
Page(s): 292-302
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.51(04) [April 2013]

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