Please use this identifier to cite or link to this item:
Title: Synthesis of 4-thiazolidinone and 2-azetidinone derivatives of 2-trifluoromethyl- 1,8-naphthyridine as antibacterial agents
Authors: Mogilaiah, K
Rao, R Babu
Reddy, K Narender
Issue Date: Jul-1999
Publisher: NISCAIR-CSIR, India
Abstract: Ethyl 2-trifluoromethyl- 1,8-naphthyridine-3-carboxylate 3 has been synthesized by the condensation of 2- aminonicotinaldehyde 1 with ethyl trifluoroacetoacetate 2 and subjected to hydrazinolysis with refluxing hydrazine hydrate to give 2-trilluoromethyl-1,8-naphth yridine-3-carboxylic acid hydrazide 4. The acid hydrazide 4 reacts with aromatic aldehydes to yield the corresponding 2-trilluoromethyl -1,8-naphthyridine-3-carboxylic acid arylidenehydrazides 5. Cyclocondensation of 5 with mercaptoacetic acid in DMF in the presence of anhyd. ZnCl2 affords 2-aryl-3-(2- trifluoromethyl-1,8-naphthyridine-3-carbonylalllino)-4-thiazolidinones 6. On the other hand, cycloaddition of chloroacetyl chloride to 5 in dioxane in the presence of Et3N gives 4-aryl-3-chloro-1-(2-trilluoromethyl-1,8 -naphthyridine-3-carbonylamino)-2-azetidinones 7. These compounds have been characterized on the basis of elemental analysis. IR, 1H NMR and MS. All the products have been evaluated for antibacterial activity.
Page(s): 818-822
Appears in Collections:IJC-B Vol.38B(07) [July 1999]

Files in This Item:
File Description SizeFormat 
IJCB 38B(7) 818-822.pdf958.74 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.