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dc.contributor.authorMogilaiah, K-
dc.contributor.authorReddy, P Raghotham-
dc.contributor.authorBabu Rao, R-
dc.description.abstractCondensation of 2-aminonicotinaldehyde 1 with p-acetamido-acetophenone 2 affords 2-(p-acetamidophenyl)-1,8-naphthyridine 3, which on acidic hydrolysis yields 2-(p-aminophenyl)-1,8- naphthyridine 4. The amino compound 4 undergo condensation with aromatic aldehydes to give corresponding 2-(p-arylideneaminophenyl)- 1,8-naphthyridines 5. Cyclocondensation of 5 with mercaptoacetic acid and β-mercaptopropionic acid separately in DMF in the presence of anhyd. ZnCI2 results in the formation of 1,8-naphthyridinyl-4- thiazolidinones 6 and 1,8- naphthyridinyl- 1,3-thiazin-4-ones 7, respectively. On the other hand, the arylidene derivatives 5 on cycloaddition with chloroacetyl chloride in the presence of triethylamine in dry 1,4-dioxane furnishes the desired 1,8-naphthyridinyl-2-azetidinones 8. The structures of the compounds 3-8 have been established on the basis of their elemental analyses and spectral (IR, 1H NMR and mass) data. Some of the compounds have been screened for their antibacterial and antifungal activities.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.38B(04) [April 1999]en_US
dc.titleSynthesis and antimicrobial activity of 1,8- naphthyridinyl-4-thiazolidinones/1,3-thiazin- 4-ones/2-azetidinonesen_US
Appears in Collections:IJC-B Vol.38B(04) [April 1999]

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