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Title: A facile phase-transfer catalysed synthesis of some β-ketosulphones
Authors: Ramaiah, K
Dubey, P K
Ramanatham, J
Issue Date: Mar-1999
Publisher: NISCAIR-CSIR, India
Abstract: Reaction of phenacyl chloride with sodium benzenesulphinate in refluxing alcohol for 10-12 hr results in the formation of phenylsulphonylacetophenone in about 50% yield. However, use of triethylbenzylammonium chloride as phase-transfer catalyst in acetonitrile medium at room temp. gives the product in over 90% yield in 30 min's, reaction time. Optimum conditions are described for the above reaction by changing the solvent, catalyst, temperature and the type of phase-transfer catalysis itself. Using the optimum conditions, several -β ketosulphones have been synthesised in a facile manner by changing the -haloketone and sulphinate salts.
Page(s): 297-301
Appears in Collections:IJC-B Vol.38B(03) [March 1999]

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