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Title: Condensation of 3-methyl/ethyl-5-mercapto-s-triazole with 3-acetylcoumarin and its derivatives
Authors: Vardhan, V Aditya
Kumar, V Ravi
Rao, V Rajeswar
Issue Date: Jan-1999
Publisher: NISCAIR-CSIR, India
Abstract: 3-Methyl/ethyl-5-mereapto-s-triazoles 2 on condensation with either 3-(2 -bromoacetyl)coumarins or with substituted 3-acetyl comarins using  bromine in the presence of trichloro-(N,N'-ethylene-bis-aminobenzamide) lanthanum and samarium as a catalyst, followed by cyclization of the intermediate 3-alkyl-5-coumarinacyl-thio-s-triazole 3 using PPA furnish 3-alkyl-5-coumarinylthiazolo[3,2-b]-s-triazoles 4 and not the isomeric 3-alkyl-5-coumarinylthiazolo [2,3 –c]-s-triazoles 6. 2-Acetyl- or 2- propanoylhydrazino-4-coumarinyl-thiazolo hydrobromides 5, obtained from the reaction of acetyl/propanoyl thiosemicarbazides 1 with either substituted 3-(2-bromuacetyl) coumarins or with bromine and substituted 3-acetylcoumarin using trichloro(N,N' -ethylene-bis-aminobenzamide)lanthanum (III) and samarium (III) as a catalyst, on treatment with phosphoryl chloride undergo facile cyclization yielding 5-alkyl-5-coumarinylthiazolo[2,3 –c]-s-triazole 6.
Page(s): 18-23
Appears in Collections:IJC-B Vol.38B(01) [January 1999]

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