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http://nopr.niscpr.res.in/handle/123456789/16188| Title: | Condensation of 3-methyl/ethyl-5-mercapto-s-triazole with 3-acetylcoumarin and its derivatives |
| Authors: | Vardhan, V Aditya Kumar, V Ravi Rao, V Rajeswar |
| Issue Date: | Jan-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3-Methyl/ethyl-5-mereapto-s-triazoles 2 on condensation with either 3-(2 -bromoacetyl)coumarins or with substituted 3-acetyl comarins using bromine in the presence of trichloro-(N,N'-ethylene-bis-aminobenzamide) lanthanum and samarium as a catalyst, followed by cyclization of the intermediate 3-alkyl-5-coumarinacyl-thio-s-triazole 3 using PPA furnish 3-alkyl-5-coumarinylthiazolo[3,2-b]-s-triazoles 4 and not the isomeric 3-alkyl-5-coumarinylthiazolo [2,3 –c]-s-triazoles 6. 2-Acetyl- or 2- propanoylhydrazino-4-coumarinyl-thiazolo hydrobromides 5, obtained from the reaction of acetyl/propanoyl thiosemicarbazides 1 with either substituted 3-(2-bromuacetyl) coumarins or with bromine and substituted 3-acetylcoumarin using trichloro(N,N' -ethylene-bis-aminobenzamide)lanthanum (III) and samarium (III) as a catalyst, on treatment with phosphoryl chloride undergo facile cyclization yielding 5-alkyl-5-coumarinylthiazolo[2,3 –c]-s-triazole 6. |
| Page(s): | 18-23 |
| Appears in Collections: | IJC-B Vol.38B(01) [January 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(1) 18-23.pdf | 1.14 MB | Adobe PDF | View/Open |
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