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Title: Protective effect of eicosapentaenoic acid-docosahexaenoic acid and α–linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats
Authors: Sengupta, Avery
Ghosh, Mahua
Keywords: Alpha-Linolenic acid;Antioxidant enzymes;Docosahexaenoic acid;Eicosapentaenoic acid;Hypercholesterolemia;Lipid profile;Neurotransmitter amino acids;Sterol esters
Issue Date: Mar-2013
Publisher: NISCAIR-CSIR, India
Abstract: With a view to investigate the ameliorative effects of sitosterol esters against degenerative effects of hypercholesterolemia brain antioxidant enzyme assays, brain lipid profile, brain phospholipid compositional change and brain neurotransmitter concentrates (glutamic acid, asparctic acid, glycine) were measured in hypercholesterolemic rats. The results indicated that phytosterol esters have a role in countering hypercholesterolemia-related changes in the brain by decreasing the cholesterol levels, increasing the phospholipid levels and increasing the level of antioxidant enzymes. The results suggest that phytosterol esters may be of therapeutic significance and may offer new and effective options for the treatment of hypercholesterolemia-induced changes in the brain.
Page(s): 241-248
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.51(03) [March 2013]

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