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Title: Effect of newly isolated Lactobacillus ingluviei ADK10, from chicken intestinal tract on acetaminophen induced oxidative stress in Wistar rats
Authors: Mandal, Arpita
Paul, Tanmay
Roy, Suchismita
Mandal, Shreya
Pradhan, Shrabani
Mondal, Keshab Ch.
Nandi, Dilip Kumar
Keywords: Acetaminophen;Free radical scavenging activity;Lactobacillus ingluviei ADK10;Oxidative stress
Issue Date: Feb-2013
Publisher: NISCAIR-CSIR, India
Abstract: The total antioxidative activity of L. ingluviei ADK10 isolated from chicken intestine intact cells and cell free culture supernatant (CFCS) was 54- 67.95%. The ability to scavenge a,a-Diphenyl-b-Picrylhydrazyl free radical ranged from 71 and 64% in intact cells and CFCS respectively. Total reducing activity of bacteria was equivalent to 290 µM/L of cysteine. Reducing glutathione activity was equivalent to 93.95µg/mL. Oral administration of the strain at a dose of 109 cfu/kg body weight to acetaminophen induced oxidative stress in rats increased catalase, glutathione and superoxide dismutase activity in the blood, liver and kidney and lowered malondialdehyde level. The results indicate that L. ingluviei ADK10 has potential free radical scavenging activity for the treatment of oxidative stress related disease.
Page(s): 174-180
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.51(02) [February 2013]

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