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dc.contributor.authorPradhan, Vandana-
dc.contributor.authorHire, Harshada-
dc.contributor.authorGhosh, K-
dc.identifier.issn0975-0967 (Online); 0972-5849 (Print)-
dc.description.abstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by genetic and epigenetic alterations as well as environmental factors. SLE is a multisystem disease whose pathogenesis is poorly understood. Current therapies are based on nonspecific immunosuppression but till date no permanent cure has been documented for SLE. Recent advances in RNA interference have opened new directions for SLE pathogenesis, more significant being the discovery of microRNAs (miRNAs). miRNAs are small, evolutionary conserved, non-coding, RNA molecules. Emerging evidences show that miRNAs affect the stability and translational efficiency of messenger RNAs (mRNAs) by post transcriptionally regulating gene expression of the target mRNAs. miRNAs play a vital role in development, regulation and prevention of immune diseases. The potential of miRNAs as diagnostic biomarkers and therapeutic agents is extensively studied by researchers worldwide. In this article, various miRNAs associated with SLE pathogenesis and their associated mechanisms in cellular processes have been reviewed. en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJBT Vol.11(2) [April 2012]en_US
dc.subjectAutoimmune disorderen_US
dc.subjectmicroRNA (miRNA)en_US
dc.subjectsystemic lupus erythematosus (SLE)en_US
dc.titleMicroRNA profile in understanding pathogenesis of systemic lupus erythematosusen_US
Appears in Collections:IJBT Vol.11(2) [April 2012]

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