Please use this identifier to cite or link to this item:
Title: MicroRNA profile in understanding pathogenesis of systemic lupus erythematosus
Authors: Pradhan, Vandana
Hire, Harshada
Ghosh, K
Keywords: Autoimmune disorder;microRNA (miRNA);systemic lupus erythematosus (SLE)
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by genetic and epigenetic alterations as well as environmental factors. SLE is a multisystem disease whose pathogenesis is poorly understood. Current therapies are based on nonspecific immunosuppression but till date no permanent cure has been documented for SLE. Recent advances in RNA interference have opened new directions for SLE pathogenesis, more significant being the discovery of microRNAs (miRNAs). miRNAs are small, evolutionary conserved, non-coding, RNA molecules. Emerging evidences show that miRNAs affect the stability and translational efficiency of messenger RNAs (mRNAs) by post transcriptionally regulating gene expression of the target mRNAs. miRNAs play a vital role in development, regulation and prevention of immune diseases. The potential of miRNAs as diagnostic biomarkers and therapeutic agents is extensively studied by researchers worldwide. In this article, various miRNAs associated with SLE pathogenesis and their associated mechanisms in cellular processes have been reviewed.
Page(s): 129-133
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.11(2) [April 2012]

Files in This Item:
File Description SizeFormat 
IJBT 11(2) 129-133.pdf111.06 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.