Evaluation of adaptogenic activity profile of a compound Ayurvedic formulation<i style=""> - Amalakayas</i> <i style="">Rasayana</i>

Abstract

The present study was undertaken to evaluate adaptogenic activity profile of a classical compound Ayurvedic formulation <i style="">Amalakayas Rasayana</i> in experimental animals. <i style="">Amalakayas</i> <i style="">Rasayana</i> (AR) was tested for its adaptogenic activity by determining anti-stress and anti-ulcer activity in forced swimming induced hypothermia and stress induced gastric ulcers. AR was administered in the dose of 270 mg/kg orally for 7 consecutive days prior to forced swimming induced hypothermia and stress ulcers. The adaptogenic and anti-ulcer activities were assessed by determining and comparing the changes in rectal temperature, ponderal changes, ulcer index, haematological parameters and anti-oxidant activity in the test drug group with that of stress control group as well as vehicle control group. In forced swimming<b style=""> </b>hypothermia pre-treatment with AR caused significant attenuation of rectal temperature when compared with both stress control and vehicle control groups. It has shown a significant reduction in ulcer index and lipid peroxidation. Moreover, AR did show a significant increase in total glutathione content. The<b style=""> </b>results suggest that AR possesses significant adaptogenic and anti-stress activity which could be either due to attenuation of stress induced stimulation of HPA axis and cytoprotective action of the test formulation.