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Title: A comparative evaluation of cardioprotective activity of two Makandi (Coleus forskohlii Willd.) formulations against isoproterenol induced myocardial infarction in hyperlipidaemic rats
Authors: Jagtap, Madhavi
Ashok, B K
Chavan, Sulakshan S
Chandola, H M
Ravishankar, B
Keywords: Cardioprotective;Coleus forskohlii;Hyperlipidaemia;Makandi;Makandi churna;Makandi ghanavati;Myocardial infarction
Issue Date: Sep-2011
Publisher: NISCAIR-CSIR, India
IPC Code: A61K 36/53, A61K 125/00, A61P 9/00
Abstract: The present study was undertaken to evaluate cardioprotective activity of Makandi (Coleus forskohli Willd.) Churna and Ghanavati on the basis of electrocardiographic, biochemical, cardiac output and histopathological parameters against isoproterenol (ISO) induced myocardial infarction in diet induced hyperlipidaemic rats. The drug treatment and hyperlipidaemic diets were administered for 20 consecutive days. Myocardial injury was induced by injecting ISO (85 mg/kg) to rats at an interval of 24 h for two days. Forty eight hours after the first dose of ISO injection, parameters like ECG, cardiac output, biochemical and histological observations of the heart tissues were performed. Hyperlipidaemic diet followed by ISO significantly increased heart weight, altered serum lipid profiles, SGPT and ALP activity, caused ST segment elevation, prolonged QT interval and QTc in ECG, increased blood pressure and decreased cardiac output. Histopathologically also, heart showed severe cytoarchitectural disturbances like myonecrosis, fatty changes and endocardial oedema. When administered orally, both the formulations of Makandi decreased atherogenic index, almost normalized ST segment elevation, QT interval prolongation and cardiac output. Histopathologically also remarkable protection was observed. Analysis of the results showed that Makandi in Churna form has both anti-atherogenic potential and cardioprotective activity, while Ghanavti has only weak cardioprotective activity.
Page(s): 335-344
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(3) [September 2011]

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